01 One hundred milligrams is a real tablet, 200 mg is the usual labeled day
One hundred milligrams is the Provigil tablet this leaf locks. The bottle also comes as 200 mg. Adult labeling for narcolepsy, obstructive sleep apnea, and shift-work disorder uses 200 mg once daily. Doses to 400 mg have been tried; the insert says they do not consistently beat 200 mg. A 100 mg start is a real clinical choice in older or sensitive people. It is not a license to crush weekends.
Narcolepsy and OSA: morning swallow. OSA still needs the airway treatment. Modafinil does not replace CPAP. Shift-work disorder: about one hour before the shift. The SWD trial used 200 mg. If your tablet is 100 mg, that is a prescribed half-rung, not a DIY split of someone else's 200.
Schedule IV. Sharing the blister is diversion. The night-shift margin is the clock file. The CYP ink is the contraceptive and cyclosporine file.
| Setting | Labeled swallow on Provigil |
|---|---|
| 100 mg tablet | Virena lock; 200 mg is the usual adult labeled daily amount |
| Narcolepsy or OSA | Morning; OSA still needs the airway plan |
| Shift-work disorder | About 1 hour before the shift (label uses 200 mg) |
| Steroidal contraceptive | Backup during treatment and for 1 month after the last tablet |
02 Write the last 100 mg date next to the backup method
Steroidal contraception needs backup through treatment and for one month after the last tablet. The insert does not give a 100 mg exception. Last week is not a month.
If you restart, the month-after clock resets when you stop again. Night workers bury this under the shift talk. Put the reminder on the same slip as the swallow hour. The CYP ink is that file.
Cyclosporine troughs can fall when an inducer starts and rise when it leaves. Transplant desks need dates. Do not restart 100 mg to "fix" a high level and do not skip cyclosporine on your own.
Schedule IV: the tablet stays in your name. A roommate's exam week is not a labeled use and is not a reason to scramble someone else's contraceptive plan.
03 Thirty 100 mg tablets on the literacy strip
Thirty 100 mg tablets is the Virena lock. Two-hundred-milligram tablets are another NDC. Schedule IV rules apply at the counter. This leaf does not invent a brand dollar beyond the sourced generic snapshot in the strip.
Generic modafinil 100 mg x 30, GoodRx Provigil table, 23 June 2026.
Generic modafinil 100 mg, thirty tablets, the Virena Provigil leaf lock, August 2026. GoodRx lists 100 mg x 30 at $662.23 average retail and $24.05 with a coupon (23 June 2026). Two-hundred-milligram tablets are another NDC. Schedule IV. Virena does not dispense.
04 What 100 mg is not for
Weekend housework. Jet lag without an SWD diagnosis. Weight loss. A hangover. A child's exam. Those uses are how Schedule IV tablets leave the house.
It does not treat OSA. It does not treat the sleepiness of uncontrolled depression as a first move. It does not replace a sleep opportunity you still owe.
05 How 100 mg sits beside a CPAP, not instead of it
If the diagnosis is OSA sleepiness, the airway plan stays. A morning 100 mg tablet can lift residual sleepiness. It does not stent an airway. Skipping the mask because the tablet felt clean is how a night drive gets dangerous.
Do not save the 100 mg for 16:00 when the mask night was short. A late tablet wrecks the next sleep and still does not replace the mask. The wake margin is for SWD clocks, not for leftover OSA hours.
Alcohol after a "successful" tablet is still alcohol. Fitness-for-duty is not a Bordeaux clearance. This leaf will not sign a route.
If a new rash or a psychiatric turn shows up, stop-and-call. Do not take tomorrow's 100 mg to see if the mask night fixes the rash. Those rows outrank a shift.
06 Fifteen hours, two enantiomers, one morning or one pre-shift
Modafinil is a racemate. R-modafinil lasts about three times longer than S. At steady state the trough is mostly R. Effective elimination half-life after multiple doses is about 15 hours. Steady state in 2-4 days. That is why a Thursday 100 mg does not vanish before a Friday night shift if you also took Thursday morning.
Food can delay the peak slightly. It is not the Viagra high-fat story. Alcohol is still a poor partner on a night drive home.
Armodafinil is a different tablet. Do not convert milligram-for-milligram from a Nuvigil leftover. Do not stack both.
| Absorption | Oral; peak delayed a little by food. |
|---|---|
| Distribution | Moderate protein binding. |
| Metabolism | Hepatic; amide hydrolysis plus CYP; weak CYP3A induction. |
| Excretion | Effective t½ about 15 hours after multiple doses; sulfone metabolite longer. |
07 Do not stack another wake tablet
Armodafinil is a different tablet. Do not convert milligram-for-milligram from a Nuvigil leftover. Do not take both.
Methylphenidate or amphetamine from an ADHD bottle plus 100 mg modafinil is a two-desk problem. This leaf will not coach a stack for a call night.
Caffeine by the pot on top of 100 mg is how tremor and a pulse story start. You do not need a third lever.
The CYP ink still applies on ordinary day shifts: backup contraception through one month after the last tablet. Cyclosporine levels can fall. Say the start date.
08 CYP3A4 induction and a month of backup contraception
Modafinil induces CYP3A4/5 enough to lower steroidal contraceptives, cyclosporine, midazolam, and triazolam. The counseling line is backup contraception during treatment and for one month after the last tablet. That month is easy to forget when you stop for a holiday.
CYP3A4 inhibitors (ketoconazole-type) and inducers (carbamazepine, rifampin) move modafinil the other way. This is the CYP ink in one paragraph so the leaf is not only a shift clock.
Cyclosporine levels can drop. That is a transplant-desk problem, not a "take 100 mg anyway" problem. Show the team the Provigil start date.
09 How to take a 100 mg tablet on a day that is actually a day
If the diagnosis is narcolepsy or OSA sleepiness, swallow 100 mg in the morning. Do not save it for 16:00 "when I slump." A late tablet wrecks the next night's sleep and still does not replace CPAP.
If the diagnosis is SWD, use the wake margin hour-before-shift clock. Do not also take a morning 100 mg "for errands."
Food can delay the peak a little. It is not a sildenafil fat ban. Alcohol still undoes a night drive home.
Missed morning: take it when you remember if it is still morning. Skip a 21:00 catch-up. You will not sleep, and you may still be wired into tomorrow's tablet.
Schedule IV: the tablet stays in your name. A roommate's exam week is not a labeled use.
10 It promotes wake. It does not deposit sleep in a bank
People treat modafinil like stored sleep. It is not. You still owe a sleep opportunity. Taking 100 mg at 16:00 "to finish a paper" and then 100 mg at 23:00 "for the night shift" is two decisions stacked, not clever chronobiology.
Serious rash, including Stevens-Johnson, is a labeled stop. Psychiatric adverse effects - anxiety, mania, hallucinations, suicidal thinking - are a stop-and-call, not a coffee chaser. Chest pain or a racing pulse is the same.
Elderly clearance can fall. Severe hepatic impairment needs a lower dose on the insert's special-population line. Severe renal failure did not move parent modafinil much in a 200 mg study, but the acid metabolite rose. This leaf will not invent a CrCl table the PI does not print.
11 Stop-and-call rows that outrank a night shift
A spreading rash, blistering, or mucosal involvement: stop. Stevens-Johnson is a labeled reason. Do not take the next 100 mg to see if it fades on the unit.
Anxiety that turns to mania, hallucinations, or suicidal thinking: stop-and-call. This is not extra coffee. Chest pain or a racing pulse is the same.
Elderly people can run higher levels. A 100 mg lock is often why they are not on 200 mg. Do not "make up" to 200 mg because a younger colleague takes that.
Severe hepatic impairment needs the insert's lower-dose line. Severe renal failure did not move parent modafinil much in a 200 mg study, but the acid metabolite rose. Do not invent a CrCl table. Ask.
12 When 100 mg is already the lower rung
Elderly people can run higher levels. A 100 mg lock is often why they are not on 200 mg. Do not "match" a younger colleague's 200 mg because a night felt long.
Severe hepatic impairment needs the insert's lower-dose line. Severe renal failure did not move parent modafinil much in a 200 mg study, but the acid metabolite rose. Do not invent a CrCl table. Ask.
Armodafinil leftovers are a different tablet. Do not convert milligram-for-milligram. Do not take both. Caffeine by the pot on top of 100 mg is a third lever you do not need.
Mail [email protected] if a sentence implied 100 mg was the SWD trial dose. The studied swallow was 200 mg about an hour before the shift.
13 One wake tablet, one clock, one month of backup
Take 100 mg when the order says morning or pre-shift. Do not bank sleep. Keep contraceptive backup for a month after the last tablet. Elise dates the bind. She does not write a night-shift roster.
[email protected] for copy. France: 15 or 112.
Morning 100 mg for narcolepsy or OSA sleepiness. About one hour before a night shift when the diagnosis is SWD. The SWD trial used 200 mg. This site's lock is the 100 mg tablet. Do not add a second 100 mg at the 02:00 slump. Do not also swallow a morning tablet for chores on a night-shift day.
It promotes wake. It does not bank sleep. CPAP stays if OSA is the diagnosis. A spreading rash or a psychiatric turn is stop-and-call, not a coffee chaser. Elderly clearance can fall. Severe hepatic impairment needs the insert's lower-dose line.
Backup contraception runs through treatment and one month after the last tablet. No 100 mg exception. Cyclosporine can fall. Midazolam can shorten. Say the start date. The CYP ink is that file. The wake margin is the night clock.
Schedule IV: the blister stays in your name. Weekend housework, jet lag without SWD, and a child's exam are not labeled uses. Armodafinil is a different tablet. Do not convert and do not stack.
Mail [email protected] if a sentence implied 100 mg was the studied SWD dose. It was 200 mg about an hour before the shift.
Write the last 100 mg date on the same slip as the backup method. A holiday stop with the same ethinyl-estradiol pack is the easy miss. Keep backup through one month after. Do not start 100 mg for jet lag without an SWD diagnosis just because a night flight felt long. That scramble is how contraceptive plans get rewritten by a suitcase tablet.
If a new rash spreads or mood turns strange on a unit, stop the next 100 mg. Do not wait for handover to finish the blister. Chest pain or a racing pulse is the same stop-and-call row.
Severe hepatic impairment needs the insert's lower-dose line. Do not match a younger colleague's 200 mg because a night felt long. Caffeine by the pot on top of 100 mg is a third lever you do not need. Armodafinil leftovers stay a different tablet. Do not convert milligram-for-milligram.
Missed morning: take 100 mg when you remember if it is still morning. Skip a 21:00 catch-up. You will not sleep, and you may still be wired into tomorrow's tablet. Food can delay the peak a little. It is not a sildenafil fat ban.